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Showing posts with label nanolipogel. Show all posts
Showing posts with label nanolipogel. Show all posts

July 17, 2012

Nanolipogel delivers multiple cancer treatments to boost survival rates

NSF - researchers have developed a novel system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to counter the cancer's secretions, resulting in a powerful therapy that, in mice, delayed tumor growth, sent tumors into remission and dramatically increased survival rates.


This illustration depicts a nanolipogel, developed at Yale University with NSF support, administering its immunotherapy cargo. The light-blue spheres within the blood vessels and the cutaway sphere in the foreground, are the nanolipogels (NLGs). As the NLGs break down, they release IL-2 (the green specks), which helps recruit and activate a body's immune response (the purple, sphere-like cells). The tiny, bright blue spheres are the additional treatment, a cancer drug that inhibits TGF-beta (one of the cancer's defense chemicals). Credit: Nicolle Rager Fuller, NSF

Nature Materials - Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy