The V-Chip could make it possible to bring tests to the bedside, remote areas, and other types of point-of-care needs.
VChip aka volumetric bar-chart chip. Photo credit: Lidong Qin and Yujun Song.
The V-chip, short for "volumetric bar-chart chip," on the other hand, can be carried around in a pocket. It is composed of two thin pieces of glass, about 3 in. by 2 in. In between are wells for four things: (1) hydrogen peroxide, (2) up to 50 different antibodies to specific proteins, DNA or RNA fragments, or lipids of interest, and the enzyme catalase, (3) serum or other sample, and (4) a dye -- any dye will do. Initially, the wells are kept separate from each other. A shift in the glass plates brings the wells into contact, creating a contiguous, zig-zagged space from one end of the V-chip to the other.
As the substance of interest -- say, insulin -- binds to antibodies bound to the glass slide, catalase is made active and splits nearby hydrogen peroxide into water and oxygen gas. This approach is called ELISA, or enzyme-linked immunosorbent assay.
SOURCE - Methodist hospital system
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