October 05, 2012

Predicted sequence of Antiaging rejuventation

FightingAging.org which closely tracks life extension research provides their educated guess at the sequence of rejuvenation therapies.

1) Destruction of Senescent Cells

A team of Spanish scientists has developed an intelligent nanodevice that lays the foundation for the future development of new therapies against aging. The device consists of nanoparticles that can selectively release therapeutic use substances in aged human cells. Its potential ranging from the treatment of diseases involving cellular degeneration or tissue such as cancer, Alzheimer's or Parkinson's, among others, to accelerated aging pathologies (progerias).

"The nanodevice is that we have developed containing mesoporous nanoparticles in the galactooligosaccharide which one outer surface prevents the exit o
f the load and that selectively opens in degenerative phase cells or senescent cells.

2) Selective Pruning and Support of the Immune System

One of the reasons for immune system decline is crowding out of useful immune cells by memory immune cells that serve little useful purpose. Targeted killing of the useless immune memory cells using processes like those mentioned above would be helpful.

Culling the immune system will likely have to be supported with some form of repopulation of cells. It is already possible to repopulate a patient's immune system with immune cells cultivated from their own tissues, as demonstrated by the limited number of full immune system reboots carried out to cure autoimmune disorders. Alternatives to this process include some form of tissue engineering to recreate the dynamic, youthful thymus as a source of immune cells - or more adventurous processes such as cultivating thymic cells in a patient's lymph nodes.

3) Mitochondrial Repair

4) Reversing Stem Cell Aging

5) Clearing Advanced Glycation Endproducts (AGEs)

AGEs cause inflammation and other sorts of mischief through their presence, and this builds up with age. Unfortunately, research on breaking down AGEs to remove their contribution to degenerative aging has been a very thin thread indeed over the past few decades: next to no-one works on it, despite its importance, and very little funding is devoted to this research.

6) Clearing Aggregates and Lysomal Garbage

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