The authors report on successful in vitro tests in the journal Dental Materials and say they’re already seeing promising results with in vivo tests on rats and rabbits. It’s possible that doctors will be able to custom order replacement bone tissue in a few years, said Susmita Bose, co-author and professor in WSU’s School of Mechanical and Materials Engineering.
If a doctor has a CT scan of a defect, we can convert it to a CAD file and make the scaffold according to the defect,” Bose said.
The material grows out of a four-year interdisciplinary effort involving chemistry, materials science, biology and manufacturing. A main finding of the paper is that the addition of silicon and zinc more than doubled the strength of the main material, calcium phosphate.
The researchers – who include mechanical and materials engineering Professor Amit Bandyopadhyay, doctoral student Gary Fielding and research assistant Solaiman Tarafder - also spent a year optimizing a commercially available ProMetal 3D printer designed to make metal objects.
The printer works by having an inkjet spray a plastic binder over a bed of powder in layers of 20 microns, about half the width of a human hair. Following a computer’s directions, it creates a channeled cylinder the size of a pencil eraser.
After just a week in a medium with immature human bone cells, the scaffold was supporting a network of new bone cells.
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