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October 17, 2011

Nano-channels for molecule delivery - and atomically precise 3D construction?

Center for Responsible Nanotechnology - Nano-channels for molecule delivery - and construction?

Chris Phoenix suggests extending recent research into a larger molecularly precise construction system.

Molecules can be delivered through a tiny channel templated by one strand of DNA.

Ohio State university uses electricity to “shoot” bits of therapeutic biomolecules through a tiny channel and into a cell in a fraction of a second.

Nature Nanotechnology - Nanochannel electroporation delivers precise amounts of biomolecules into living cells

The developers are using nanochannel elaporation to deliver precise amounts of chemicals through the membrane of individual cells. This is highly cool, with all sorts of research implications. And eventually, perhaps therapeutic implications - they're talking about scaling it up to process 100,000 cells at a time.

So I got to wondering: If someone loaded up these reservoirs with two kinds of molecules, that would stick to each other but not to themselves, could this be used as an ink-jet printer at the nanoscale?




For starters, use one kind of molecule that will stick to a surface. Squirt it on and see if it worked. Then, scan the tip while you squirt.

Once you start using multiple kinds of molecules, you can perhaps build 3D structures. And with a patterned surface, it might be possible to get atomic precision.

With a million addressible reservoirs, and 10 ms per 1-nm voxel, it would be possible to build the volume of a human cell in a few hours.


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