Panetta said intelligence gathered during the raid at Osama bin Laden's compound has lead the United States to target 10-20 key al Qaeda leaders.
"If we can go after them, I think we really can strategically defeat al Qaeda," Panetta said.
"I think we have them on the run," Panetta said. "I think now is the moment, following what happened with bin Laden, to put maximum pressure on them, because I do believe that if we continue this effort we really can cripple al Qaeda as a threat to this country.
"Is it going to take some more work? You bet it is. But I think it's within reach," Panetta said.
Panetta also said he believes Aymin al Zawahiri, al Qaeda's new commander, is living in the tribal areas of Pakistan, known as the FATA.
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