Diseases like polio, which has been eradicated in many countries through vaccination, are still prominent in parts of the developing world. Among the barriers to vaccination in these areas is the sensitive nature of the vaccines themselves, which must be kept at a precise temperature from manufacture to use to prevent spoiling. Poor infrastructure and unreliable power limit the reach of this cold chain, which hinders vaccination efforts
Each year approximately 25 million infants do not receive the necessary immunizations, and at least 2.4 million children die from vaccine-preventable diseases—approximately 14 percent of deaths in children under 5. Millions more survive, but are left severely impaired. The long-term effects of these childhood illnesses limit the ability of those who survive to become educated, to work, or to care for themselves or others.
More deaths could be prevented and illnesses avoided, if vaccines which are sensitive both to excessive heat and excessive cold (kept between 2 and 8 degrees celsius), were transported and stored correctly.
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