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May 10, 2011

A donated blood vessel had a patients own stem cells infused for rejection free transplant surgery

For the first time ever in the world, researchers at the Sahlgrenska Academy have produced a blood vessel from stem cells and then used it in an operation on a 10-year-old girl at the Sahlgrenska University Hospital. Surgeon and Professor Michael Olausson was able to create a new connection with the aid of this blood vessel between the liver and the intestines, necessary to cure the girl. The girl is now in good health, and her prognosis is very good.

* the blood vessel was created with the girl’s own stem cells, she does not need to take drugs to prevent rejection

* it is possible to create new blood vessels from stem cells, using a previous blood vessel as a template

* The next step is to intensify research into the recreation of other organs, and to develop methods that can be used for arteries. This can help, among others, patients who need dialysis and those needing surgery for the coronary arteries. It may also help those needing complete organs



The girl developed during her first year of life a blood clot in the blood vessel that leads blood from the intestines to the liver. This introduced the risk that she would experience life-threatening internal bleeding. The condition can be cured if it is possible to direct the blood along the correct path, back into the liver. In optimal cases, the surgery can be performed using blood vessels from other parts of the patient’s body, but a liver transplant may be necessary if the surgery is unsuccessful due to a lack of sufficient blood vessels. A liver transplant will involve subsequent lifelong treatment with immunosuppressive drugs.

Blood vessels from a dead donor were used in the present case. The vessel was then chemically treated to remove all cells RNA and DNA. This left just the supporting tissue. Stem cells were then obtained from the girl’s bone marrow and these were added to the supporting tissue. A new blood vessel grew in just under four weeks. This was used during the surgery in order to create the new connection between the liver and the intestines, necessary to cure the girl.

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