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March 07, 2011

New weight loss discovery moves us closer to 'the Pill' for obesity by reducing Klotho protein

An important discovery in mice may make a big difference in people's waistlines thanks to a team of Harvard scientists who found that reducing the function of a transmembrane protein, called Klotho, in obese mice with high blood sugar levels produced lean mice with reduced blood sugar levels. This protein also exists in humans, suggesting that selectively targeting Klotho could lead to a new class of drugs to reduce obesity and possibly Type 2 diabetes for people.

Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions



Shawkat Razzaque publications

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