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August 11, 2010

Saving People from Bleeding to Death and Progress to Treating Fatal Hypertension

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1.

Gopinath Sutendra and a group of collaborators have found that excessive cell growth can be reversed. Note: excessive cell growth is one of the seven damages from aging that SENS (Strategies for Engineered Negligible Senescence ) is trying to address

Hypertension causes 5 million premature deaths each year worldwide (WHO World Health Report, 2002) and 13% of global fatalities

Pulmonary arterial hypertension is a fatal disease with no treatment options. A research group in the Faculty of Medicine & Dentistry at the University of Alberta though is one step closer to changing that.

Pulmonary hypertension, which is high blood pressure in the lungs, is caused by a cancer-like excessive growth of cells in the wall of the lung blood vessels. It causes the lumen, which is the path where blood travels, to constrict, putting pressure on the right ventricle of the heart. University of Alberta cardiovascular and cancer researcher Evangelos Michelakis, his graduate student Gopinath Sutendra and a group of collaborators have found that this excessive cell growth can be reversed by targeting the mitochondria of the cell, which control metabolism of the cell and initiates cell death.

By using dichloroacetate (DCA) or Trimetazidine (TMZ), which are mitochondria targeted pharmaceuticals, the activity of the mitochondria increases, helping induce cell death and regressing pulmonary hypertension in an animal model, says Sutendra.


2. A London School of Hygiene and Tropical Medicine (LSHTM) study revealed that early administration of tranexamic acid (TXA) to patients with recent, severe bleeding injuries saves lives, with no evidence of adverse effects from unwanted clotting.

* TXA is an off-patent drug, manufactured by a number of different companies. The cost per gram is about £3 ($4.50).

* For people aged between five and 45 years, injury is second only to HIV/AIDS as a cause of death. Each year about 600,000 injured patients bleed to death worldwide

* researchers estimate that administering TXA soon after injury could prevent up to 100,000 deaths per year across the world. In India it could save about 13,000 lives each year, with about 12,000 lives saved in China. The drug would also save lives in developed countries, around 2,000 each year in the USA and more in Europe.



3. Researchers from the UCSF asked a simple question that had never been asked before: do normal proteins form insoluble clumps when normal, healthy individuals age? yes, 700 proteins were found that become insoluable. Those "normal, health individuals" are on their way to the same end destination of neurodegeneration, just not as fast. In many neurodegenerative diseases, such as Alzheimer's and Huntington's, clumps of proteins known as aggregates appear in the patients' brains as the degeneration progresses. Those clumps contain some proteins that are unique to the specific disease (such as Abeta in Alzheimer's), intertwined with many others that are common in healthy individuals. For years, those common proteins were thought to be accidental inclusions in the aggregates, much as a sea turtle might be caught in a seine of fish. In fact, they may not be innocent bystanders at all, but instead their presence may influence the course of neurodegenerative disease.

The research highlights the importance of the amylosens project to destroy junk betweencells.



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