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September 04, 2009

Upcoming in the SENS4 conference Schedule

Talks that are scheduled for Sunday, Sept 6, 2009 at the SENS4 conference.

Session 21 Tissue engineering (Chair: Leonid Gavrilov)
Augustinus Bader Leipzig, Germany
Currently Available Therapies with Autologous Stem Cells - From Basic Principles to Clinical Application

Gabor Forgacs Columbia, USA
Organ Engineering by Bioprinting

Biomaterials-based exogenous scaffolds, though promising, still face general as well as specific challenges. Scaffolds may elicit adverse host responses and interfere with direct cell-cell interaction, as well as assembly and alignment of cell-produced extracellular matrix. Thus, fabrication techniques for production of scaffold-free engineered tissue constructs have recently emerged. Here we describe a novel fully biological self-assembly approach, which we implement through a rapid prototyping bioprinting method. The approach utilizes bio-ink particles, convenient multicellular units, either spheroids or cylinders of controlled diameter (300 to 500 μm), that are deposited with specifically designed bio-printers. The cellular composition of the bio-ink and the deposition scheme are respectively consistent with the cellular composition and topology of the desired biological construct. We use the method for scaffold-free small diameter vascular reconstruction and nerve regeneration. Various vascular cell types, including smooth muscle cells and fibroblasts, are aggregated into the bio-ink units. These are printed layer-by-layer concomitant with agarose rods, used here as a molding template. The post-printing fusion of the discrete units results in single- and double-layered small diameter vascular tubes. A unique aspect of the method is the ability to engineer vessels of distinct shapes, complex internal geometry, in case of nerve grafts, and hierarchical trees that combine tubes of distinct diameters, in the case of vascular grafts. The technique is quick and easily scalable.


Sally Dickinson Bristol, UK
The first clinical transplantation of a tissue engineered airway


Session 22 The longer term (Chair: Augustinus Bader)

Philip Moriarty Nottingham, UK
Molecular Nanotechnology in the Real World: How Feasible is a Nanofactory?

I will critically assess MNT (molecular Nanotechnology) from the perspective of an experimental nanoscientist, focussing in particular on the aims and objectives of a recently-funded programme of work on computer-controlled assembly of diamond nanostructures, e.g. via mechanosynthesis





Leonid Gavrilov Chicago, USA
Demographic consequences of defeating aging

Even for very long 50-year projection horizon [with defeat of aging], with the most radical life extension scenario (assuming no aging at all after age 50), the total population increases by 35 percent only (from 9.1 to 13.3 billion).


http://longevity-science.blogspot.com/

Nickolas Mayer Satellite Beach, USA
The Lifenaut Project: a multifaceted experiment in data storage for future machine consciousness learning

The goal of the Lifenaut Project has been to create a diverse, large-scale database consisting of real people's personality archives such that future intelligent agents can learn rapidly by uploading archived data rather than experiencing events in real time. A learning protocol such as this would increase the rate of progress in the field of machine consciousness and may be more effectively tested than real time learning protocols, since in many cases a frame of reference will exists for comparison with the replicated consciousness.

A web-based personality archiving architecture (lifenaut.com) has been created and promoted to the general public as such. Through this web-based interface anyone worldwide with an internet connection can create a "mindfile" free of charge. The mindfile consists of: personality test results, personal profile data, uploaded biographical media, and an archive of the user's lines of conversation with a chatbot. Since its kickoff in 2006, Lifenaut has undergone 3 major iterations and each user's mindfile is tapped into the iCogno chatbot engine combined with an InterMediaLab photo-based avatar. At the time of this writing 8,702 from around the globe have created Lifenaut accounts. Agents resulting from long-term user interaction with the Lifenaut software will be tested with the ConsScale 2 consciousness taxonomy (Arrables-Moreno).


Other Sessions

Sept 4, 2009

Session 5 Eliminating recalcitrant intracellular molecules: the lysosome (Chair: Alex Whitworth)

Session 6 Eliminating recalcitrant intracellular molecules: other (Chair: Ana Maria Cuervo)

Session 7 Panel discussion and short talks (Chair: John Furber)

Session 8 Short talks (Chair: Alex Zhavoronkov)

Session 9 Rejuvenating extracellular material: amyloid (Chair: Kendall Houk)

Session 10 Rejuvenating extracellular material: other (Chair: Nik Nikitin)

Sept 5, 2009

Session 11 Telomeres and telomerase (Chair: Cassian Yee)

Maria Blasco Madrid, Spain
Role of Shelterin in Cancer and Aging

Vera Gorbunova Rochester, USA
Evolution of anticancer mechanisms in short- and long-lived species

David Keefe Tampa, USA
Telomeres and Reproductive Aging


Session 12 Novel anti-cancer approaches (Chair: Vera Gorbunova)

Paul Hallenbeck Malvern, USA
Phase I study of Seneca Valley Virus (SVV-001), a replication competent oncolytic virus, in patients with neuroendocrine (NE) cancers

Adela Ben-Yakar Austin, USA
Femtosecond laser nanosurgery from shedding light on nerve regeneration to aiding in cancer diagnosis and therapy

Cassian Yee Seattle, USA
Engineering Tumor Immunity: Adoptive T Cell Therapy of Cancer

Session 13 SENS Lecture and short talks (Chair: Silvia Gravina)
Moses Znaimer Toronto, Canada
SENS Lecture: Canada - Harbinger of the Zoomer Phenomenon (Chair: Aubrey de Grey)

Natalia Gavrilova Chicago, USA
Search for mechanisms of exceptional human longevity

Mike Berridge Wellington, New Zealand
Effects of mitochondrial gene deletion on tumorigenicity of metastatic melanoma: reassessing the Warburg effect

Ülo Kristjuhan Tallinn, Estonia
Postponed Aging in University Teachers

Session 14 Short talks (Chair: Mike Berridge)

Session 15 Rejuvenating the immune system (Chair: Lusine Danielyan)
Janko Nikolich-Zugich Beaverton, USA
Why T-cells go out of whack with aging and what to do about it

Anne de Groot Providence, USA
Re-establishing Immunological Balance and Re-engineering Tolerance with Tregitopes

Omar Ali Cambridge, USA
Infection-mimicking materials to program dendritic cells in situ

Justin Rebo
SENS Foundation Research Center Senescent T cell removal using magnetic antibodies

Session 16 Delivering genes, proteins and larger structures in vivo (Chair: Janko Nikolich-Zugich)

Dieter Willbold Düsseldorf, Germany
Oral treatment with an Aβ42 oligomer modulating D-amino acid peptide improves cognitive behavior of APP/ PS1 double transgenic mice

Lusine Danielyan Tübingen, Germany
Intranasal delivery of cells to the brain

Carlos Barbas La Jolla, USA
Synthesis of programmable integrases

Sunday 6th September

Session 17 Novel routes to the ES-like phenotype (Chair: Daniel Kraft)

Justin Ichida Cambridge, USA
Reprogramming Somatic Cells to Pluripotency Using Small Molecules

Ilham Abuljadayel London, UK
Retrodifferentiation and Aging: Harnessing Youth through Induction of Pluripotency in mature adult cells via Cell Surface Receptor Contact

Khachik Muradian Kiev, Ukraine
"ORION" - a glimpse of hope in life span extension?

Vadim Fraifeld Beer-Sheva, Israel
MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets?


Session 18 Recent advances in cell therapies (Chair: Ilham Abuljadayel)

Daniel Kraft Stanford, USA
Manipulation and Derivation of the Hematopoitic Stem Cell Niche

Gene Redmond Thousand Oaks,
USA Cellular repair in the non-human primate brain with human neural stem cells and multiple fetal cells grafts.

Hadi Aslan Jerusalem, Israel
Engineered Mesenchymal Stem Cells - The Road to Skeletal Tissue Regeneration

Session 19 Panel discussion and short talks (Chair: James Morré)
James Larrick Sunnyvale, USA
Panel Discussion: Applied Healthspan Engineering

Dazhong Yin Guangzhou, China
Preventive Treatment of Traditional Chinese Medication as Anti-stress and Anti-aging Strategy

Jwala Sinha Palamau, India
Strategies for adjustment of the aged

John Furber Gainesville, USA
Extracellular Aging: Issues for Therapy Design


Session 20 Short talks (Chair: James Larrick)
Gunther Kletetschka Greenbelt, USA
Crack avoidance during cryopreservation attempts

Sonya Vasto Palermo, Italy
Parental longevity impacts on the healthy ageing of their offspring: Effects on blood and clinical chemistry parameters in centenarians' offspring

Noel Patton New York, USA
Recent progress in pharmacological amelioration of telomere shortening

David Williams Cambridge, UK
Cataract development as a model of ageing - a comparative approach

Michael Colgan Salt Spring Island, Canada
Combined chemical and brain stimulation induction of neurogenesis in brain injury and brain degeneration of aging.

D. James Morré West Lafayette, USA
Aging related NADH oxidase (arNOX) response to dietary supplementation . The French Paradox revisited

Joshua Mitteldorf Philadelphia, USA
Accumulated Damage is not the Root Cause of Aging



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