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April 24, 2009

US Army has Anti-Aging Projects

Army is taking submissions for anti-aging research.

Wired blogged about the army's anti-aging projects.

If the military can combine the potential of resveratrol with the power of the mole rat. In February, biochemists at the University of Texas Science Center expanded the mitochondrial theory, based on a study of the unbreakable proteins in mole rats, who outlive lab mice by around 20 years. Their work suggests that efficient mitochondria and resilient proteins may work in tandem to promote longevity. Scientists are now trying to determine the "protein protectant" that keeps the rats so darn frisky.



A09-059 TITLE: The Energetics of Cognitive Performance: Regulation of Neuronal Adenosine Triphosphate Production

TECHNOLOGY AREAS: Biomedical, Human Systems

OBJECTIVE: To optimize neuronal adenosine triphosphate production capacity.

DESCRIPTION: The modern Army is constrained by mitochondria. Mitochondria are the batteries of eukaryotic cells, and mitochondrially produced ATP is the energy that enables cognitive and physical performance in multicellular organisms. Mitochondrial insufficiency due to aging is directly correlated with reduced ATP production which in turn reduces physical and cognitive performance capabilities in humans. Highly qualified and very experienced soldiers regularly leave the Army because their physical and/or cognitive performance capabilities are significantly less than that of a 20 year old. Although people older than 42 are not eligible to join the Army, little has been done to reduce the effect of old mitochondria on DoD capabilities. At present, individuals attempt to counter their mitochondrial decline with frequent exercise and antioxidants, both of which are crude methods with limited effectiveness. A more precise methodology to stimulate mitochondrial energy production when needed would improve soldier cognitive and performance capabilities, and extend the time that soldiers remain fit for duty.

The past twenty years have seen a revolutionary breakthrough in understanding how mitochondria function. Human mitochondria are a network of approximately 2,000 proteins, exquisitely integrated into a larger network of approximately 100,000 cellular proteins, and again functionally integrated into a larger network of 3 billion cells. Sequence data is available for both the human nuclear and the mitochondrial genome. The biochemical basis of oxidative phosphorylation is well understood and genetic polymorphisms leading to altered energetics and performance capabilities are well documented. The scientific understanding and the technology to develop high throughput screening to identify and characterize compounds that improve neuronal adenosine triphosphate production is now feasible.

PHASE I: Design, construct, develop, and demonstrate the feasibility a high throughput system to identify compounds that increase adenosine triphosphate production in neurons.

PHASE II: Identify compounds that have stimulatory effects on neuronal adenosine triphosphate production and are capable of crossing the blood brain barrier. Identify and characterize the mechanism of action for lead compounds using genetics, genomics, bioinformatics, and/or biochemical approaches. Select one prototype compound for pharmaceutical production and FDA approval.

PHASE III: The "vision" is a warfighter force with improved energetic capabilities; this is analogous to replacing zinc carbon batteries with silver oxide batteries – more energy production capacity will enable the warfighter to sustain demanding cognitive or physical activities longer. The expectation is that the product coming out of this phase II research would transition directly to a small or large biotechnology or pharmaceutical company that would sell the product to warfighters. As vast numbers of civilians are old, substantial civilian interest is also anticipated.







REFERENCES:

1. Balaban, R.S. Nemoto, S., and Finkel, T. 2005. Mitochondria, oxidants, and aging. Cell 120(4):483-95.

2. Beal, M.F. 2005. Mitochondria take center stage in aging and neurodegeneration. Ann Neurol 58(4):495-505.

3. Boveris, A., and Navarro, A. 2008. Brain mitochondrial dysfunction in aging. IUBMB Life; 60(5):308-14.

4. Clancy, D.J. 2008. Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background. Aging Cell [Epub ahead of print]

5. Huang, H. and Manton, K.G. 2004. The role of oxidative damage in mitochondria during aging. Front Biosci 9:1100-17.

6. Lenaz, G., Bovina, C., D’Aurelio, M., Fato, R., Formiggini, G., Genova, M.L., Giuliano, G., Merlopich, M., Paolucci, U., Castelli, G., and Ventura B. 2002. Role of mitochondria in oxidative stress and aging. Ann N Y Acad Sci 959:199-213.

7. Linford, N.J., Schriner, S.E., and Robinovitch, P.S. 2006. Oxidative damage and aging: spotlight on mitochondria. Cancer Res 1:66(5):2497-9.

8. Lopez-Lluch, G. Irusta, P.M., Navas, P., and de Cabo, R. 2008. Mitochondrial biogenesis and healthy aging. Exp Gerontol 43(9):813-9.

9. Navarro, A., and Boveris, A. 2004. Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging. Am J. Physiol Regul Integr Comp Physiol 287(5):1244-9. Keywords: mitochondria, oxidative phosphorylation, adenosine triphosphate, neurons, ATP.

KEYWORDS: mitochondria, oxidative phosphorylation, adenosine triphosphate, neurons, ATP, HTS

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