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January 15, 2009

Follistatin used to Inhibit Myostatin for Increased Strength and Muscle in Mice

Follistatin was used in mice to determine if enhanced muscle mass impacts the symptoms of spinal muscular atrophy (SMA). After treatment, the mice had increased muscle mass, gross motor function improvement and an increase in average life span of 30 percent.”

With the therapy, MU researchers inhibited myostatin, a protein that limits muscle tissue growth. Myostatin activity can be reduced significantly by enabling several proteins that bind to myostatin, including follistatin. When myostatin is inhibited, muscle mass and strength increase.


This site has covered the development of myostatin inhibitors before and believes that it will be used to safely enhance the strength, performance and health of people.

Myostatin inhibition could be four times more effective than high dosages of steroids for muscle growth.




FURTHER READING
Delivery of recombinant follistatin lessens disease severity in a mouse model of Spinal Muscular Atrophy
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