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September 01, 2008

Singapore heart stem cell transplant could replace heart bypass surgery

Singapore's National Heart Centre should start human clinical trials for stem cells for treating heart disease in one or two years. Heart disease is one of the leading causes of death worldwide. This follows recent news of using stem cells to create an unlimited disease free blood supply and the possibility of using stem cells for regeneration, rejuvenation and life extension.

If successful the new stem cell (heart cell) transplant method pioneered by the National Heart Centre (NHC), will help patients avoid the high-risk heart transplant and even eliminate the need for bypass procedures.

The method involves taking stem cells from the patient’s heart, cultivating them in a special solution to differentiate them into heart muscle stem cells and then transplanting these differentiated cells back into the patient’s heart.



While there is now a race to use stem cell therapy in the treatment of heart failure patients, most of the programmes are in their early phases.

The NHC, with its pre-clinical study results that it claims are “better than any other in the world” and proprietary technology to manipulate the cells, thinks it has a good chance at early success.

The NHC study has shown that heart pump action is significant in mice which have received the heart stem cells. A total of 43 patients undergoing heart bypass surgeries donated their heart stem cells for the project.

“These cells tend to be clever and can move by themselves by migration, and tend to move into areas that require them most,” said Dr Wong.

In the study, some 30 per cent of stem cells were converted into heart muscle cells under a patented method used by the NHC. This compares well against the few out of “millions” of whole stem cells poured into the heart used in conventional methods, the NHC said.

Another potential benefit of the NHC’s research is that a heart failure patient can harvest his own stem cells to be used for his own treatment — doing away with the need for immunosuppressants, or drugs that help a transplant patient cope with rejection of donor tissue.

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