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October 26, 2007

More on safer and more effective muscle enhancement

Two new classes of experimental drugs shown to have powerful muscle-building capabilities--selective androgen receptor modulators (SARMs) and myostatin inhibitors--have been added to the World Anti-Doping Agency's (WADA) list of prohibited substances for 2008.

I had discussed the myostatin inhibitor drug

I believe that there is nothing wrong with safe muscle enhancement. Unlike steroids it will improve the health of most of those who use it. Preventing deterioration of muscle in the elderly. There are some people have the activated genes which causes myostatin inhibition and there is no indication that their health is bad or that their life expectency is less.

Here is an article that describes current underground use of IGF-1 and myostatin inhibitors

IGF-1 LR3 Benefits:

Stimulates muscle growth and has been shown to benefit the heart (a muscle).
Encourages the absorption of Chondroitin Sulfate and Glucosamine Sulfate (also found in Velvet Antler).
Regenerates nerve tissue
Helps burn fat, increase protein transport into cells, and reduce protein breakdown
Improves the production of white blood cells
Decreases LDL Cholesterol

So to recap, IGF-1 provides almost permanent muscle-creating, muscle-repairing, and anti-aging benefits.

In 2004 the leading experts on the subject admitted that this gene therapy could already be in use, and that the technology and knowledge is such that the process to deliver it isn’t complicated.




Being able to deliver genetic modification to every cell

A review of research for using gene therapy to enhance humans

Back in 2002, University of Pennsylvania gene therapy researcher Lee Sweeney studied ways to treat muscular dystrophy and the general frailty that comes with aging. In his lab, he inserted a gene called IGF-1 into the muscles of mice. The IGF-1 gene effect is being mimicked by the new myostatin inhibitors.

"The good this can bring to people with muscle disease and the elderly far outweighs the potential downside from an athletic standpoint," he says, "so I think it's going to have to be dealt with."

6 comments:

Lobo7922 said...

Dont you think this is just too good to be true?

I dont know, that is not the way that the world works, eventually we will discover this have consequences, or at least i think that we should try and experiment a little more with this before start taking this drugs to look like Hercules ;)

bw said...

They are replicating genes that some people and animals already have. It seems reasonable that copying what is safe in some would be mostly safe in others.

Plus unlike steroids teh myostatin inhibition is just in muscles.

The experimentation will be upon million of people with muscle disease or with atrophied muscles from old age. Those people clearly would have better cost benefit because the lack of muscles is seriously harming them.

I also think that thousands of athletes will volunteer. There should be substantial case history and wide scale trials over the next 5-10 years. I personally am pencilling it in for 2017.

Jack said...

As lobo7922 just demonstrated, I bet there will be widespread suspicion about something so unnatural as a 60% increase in muscle mass in one month.

Even if there are no side effects, most people will still want it banned and criminalized just because of their biases.

bw said...

There is the likely ban for sports, but for me and I suspect many others. They would willing to be banned from sports. Especially if I was 52 in 2016, it would be largely irrelevant if I was banned from sports.

In terms of banning etc... I am sure the bans would be just as successful as the current bans and restrictions on steroids.

al fin said...

The myostatin inhibitors are particularly intriguing. It would be important to strengthen the support structures at the same time as the muscles are strengthened. Otherwise you might see more bone, ligament, and tendon injuries in the elderly and previously sedentary.

Mav said...

Researcher's Breed Mighty Mouse:

http://www.physorg.com/news113153506.html