From Forbes: Working with 17 patients with advanced, metastatic melanoma skin cancers, Rosenberg's team first removed a small sample of normal T-cells from each patient. Next, the researchers genetically engineered the cells to carry a specific cell-surface receptor, one that would help them recognize melanoma cells.
These "re-armed" cells were then introduced back into the patient's bloodstream, where it was hoped they would gradually replace less-able lymphocytes and mount a fierce, sustained attack against the cancer.
That's exactly what happened for two of the 17 patients in the study, who quickly went into a sustained remission. "These two patients were treated over a year ago and are now disease-free," Rosenberg said
This is early work, but as the procedure is optimized holds the hope of higher rates of success.
August 31, 2006
Gene Therapy supercharges immune system success versus cancer
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